2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2417):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-122524S
    7-Methylguanosine-d3
    		98.54%
    7-Methylguanosine-d3 is the deuterium labeled 7-Methylguanosine. 7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8 ± 7.5 μM.
    7-Methylguanosine-d<sub>3</sub>
  • HY-W406070
    2'-O,4'-C-Methyleneguanosine
    		99.22%
    2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analog, where LNA (locked nucleic acid) is a nucleic acid analog. LNA modification can be widely used in various fields, such as effective binding affinity with complementary sequences and stronger nuclease resistance than natural nucleotides, providing great potential for application in disease diagnosis and research. 2'-O,4'-C-Methyleneguanosine is a substrate for KOD DNA polymerase, which incorporates LNA-G nucleotides into growing DNA strands, including consecutive incorporations , to generate full-length extension products.
    2'-O,4'-C-Methyleneguanosine
  • HY-124143
    Isoguanine
    		99.64%
    Isoguanine is a purine base that is an isomer of Guanine. A building block in organic synthesis.
    Isoguanine
  • HY-W008848
    DMT-dG(ib) Phosphoramidite
    		99.71%
    DMT-dG(ib) Phosphoramidite is a phosphoramidite monomer that can be used in the synthesis of DNA and related molecules.
    DMT-dG(ib) Phosphoramidite
  • HY-W091784
    3'-O-Methylguanosine
    		99.98%
    3'-O-Methylguanosine is a methylated nucleoside analog and RNA chain terminator. 3'-O-Methylguanosine can inhibit the synthesis of early vaccinia virus-specific RNA.
    3'-O-Methylguanosine
  • HY-W013195
    8-Bromoadenosine
    		99.73%
    8-Bromoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. 8-Bromoadenosine can quench the intrinsic fluorescence of human serum albumin (HSA) through static quenching procedure. 8-Bromoadenosine can be used to synthesize adenosine phosphate, such as Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    8-Bromoadenosine
  • HY-20140
    5'-O-DMT-dT
    		99.75%
    5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative which can be used in the preparation of oligonucleotides.
    5'-O-DMT-dT
  • HY-W011518
    2′-Deoxy-2′-fluoroguanosine
    		99.90%
    2′-Deoxy-2′-fluoroguanosine is a nucleoside analog and potent influenza virus inhibitor with an EC90 value of <0.35 μM against influenza A and B viruses. 2′-Deoxy-2′-fluoroguanosine inhibits influenza virus replication in the upper respiratory tract, thereby ameliorating fever and nasal inflammation.
    2′-Deoxy-2′-fluoroguanosine
  • HY-21545
    5'-O-DMT-Bz-rA
    		98.0%
    5'-O-DMT-Bz-rA is an intermediate for cyclic di-nucleotide compounds synthesis.
    5'-O-DMT-Bz-rA
  • HY-13672
    LY2334737
    		Inhibitor 98.55%
    LY2334737 is an nucleoside analog and is an orally active proagent of Gemcitabine. LY2334737 exhibits inhibitory activity against enterovirus A71 (EV-A71) infection. LY2334737 has antiviral and anticancer effects.
    LY2334737
  • HY-W025438
    5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine
    		98.03%
    5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine is a 2'-O-methyluridine derivative bearing a 5'-O-(4,4'-dimethoxytrityl) protecting group.5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine serves as a starting material for synthesis of a conformationally rigid cyclic uridylic acid derivative.
    5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine
  • HY-103317
    NAADP
    NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling.
    NAADP
  • HY-18684
    SIBA
    		99.64%
    SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies.
    SIBA
  • HY-B1449S1
    Uridine-13C
    		99.82%
    Uridine-13C is the 13C labeled Uridine.
    Uridine-<sup>13</sup>C
  • HY-148505
    5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
    		99.17%
    5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite blongs to modified antisense oligonucleotide. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite allows the formation of a specific conformation of the furanose ring of the oligonucleotide through the introduction of a cEt modification, enhancing the ability to hybridize to complementary RNA. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is mainly used in the research of regulation of gene expression related to metabolic diseases, cardiovascular diseases, cancers and the development of antisense compounds.
    5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
  • HY-138610
    5'-O-DMT-Bz-rC
    		99.69%
    5'-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.
    5'-O-DMT-Bz-rC
  • HY-152562
    N-Propargyladenosine
    		99.13%
    N-Propargyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277). N-Propargyladenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-Propargyladenosine
  • HY-138616S4
    dGTP-13C10,15N5 dilithium
    		98.2%
    dGTP-13C10,15N5 (2'-Deoxyguanosine-5'-triphosphate-13C10,15N5) dilithium is 13C and 15N-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
    dGTP-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub> dilithium
  • HY-154578
    N1-Methyl-2'-deoxyadenosine
    N1-Methyl-2'-deoxyadenosine, DNA adduct is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-Methyl-2'-deoxyadenosine
  • HY-138586
    DMT-dC(ac) Phosphoramidite
    		99.76%
    DMT-dC(ac) Phosphoramidite (compound 30f) is a phosphoramidite derivative that can be used for the oligonucleotide synthesis.
    DMT-dC(ac) Phosphoramidite